Individualizing drug dosage by using a random intercept linear model

Individualizing drug dosage by using a random intercept linear model

Source :

• Statistics in Medicine [ 0277-6715 ] ; 2007-04-30.

English descriptors

• Teeft :
  • Algorithm, Algorithm performance, Algorithm step, Algorithm steps, American journal, Antipsychotic drug, Arbitrary values, Average loss, Bayesian, Biological psychiatry, Chronic schizophrenia, Clinical application, Clinical pharmacokinetics, Clozapine, Clozapine concentrations, Clozapine data, Clozapine dosage, Clozapine dosages, Clozapine model, Clozapine plasma levels, Comparable values, Conditional distribution, Copyright, Covariate, Covariate values, Covariates, Cumulative distribution function, Current article, Daily smokers, Developmental disabilities, Diaz, Dichotomous covariate, Dosage, Dosage adjustment, Drug concentrations, Drug dosage, Drug dosage individualization, Drug elimination, Drug individualization, Drug plasma concentration, Drug plasma concentrations, Empirical validation, Estimation errors, Estimator, Experimental subject, Female nonsmokers, Good choices, Greater likelihood, Grupos reconocidos colciencias, High probability, Independent measure, Individualization, Intraclass correlation, John wiley sons, Largest probability, Loss function, Loss functions, Male smokers, Many drugs, Maximum likelihood estimates, Metabolic, Metabolic activity, Metabolic index, Minimum number, Model parameters, More information, More pairs, National institute, Necessary algorithm steps, Optimum dosage, Optimum number, Other hand, Parameter, Parameter estimate, Parameter estimates, Particular combinations, Particular patient, Particular values, Percentile, Pharmacokinetic, Pharmacokinetic quantities, Pharmacokinetics, Plasma clozapine concentrations, Plasma concentrations, Population constants, Population level, Population pharmacokinetic models, Population pharmacokinetic parameters, Possible choices, Previous concentrations, Random intercept, Random variables, Relative percentile, Relative percentiles, Same dosage, Schizophrenia, Second question, Severe schizophrenia, Similar conclusions, Smoker, Smoking behaviour, Smoking status, Standard error, Statist, Steady state, Target concentration, Target range, Theorem part, Therapeutic window, Trough, Trough plasma clozapine concentration, Trough plasma clozapine concentrations, Trough plasma concentration, Trough plasma concentrations, True model parameters, True parameters, True values, Unexplained clozapine, Universidad nacional.

Abstract

• https://api.istex.fr/ark:/67375/WNG-798Q2BM0-D/fulltext.pdf

Affiliations:

• Colombie, Niger, États-Unis
• Kentucky, Pennsylvanie

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